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Response evaluation criteria in solid tumors - Wikipedi

  1. Response evaluation criteria in solid tumors (RECIST) is a set of published rules that define when tumors in cancer patients improve (respond), stay the same (stabilize), or worsen (progress) during treatment
  2. Some patients whose disease met the criteria for disease progression based on traditional response criteria such as RECIST (an increase in the sum of measures of target lesions, unequivocal increase in non-target disease, or the appearance of new lesions) were noted to have late but deep and durable responses. 2
  3. ing whether tumour measurement data can allow the conclusion that a patient's disease has improved, stayed about the same, or worsene
  4. Background: Assessment of the change in tumour burden is an important feature of the clinical evaluation of cancer therapeutics: both tumour shrinkage (objective response) and disease progression are useful endpoints in clinical trials. Since RECIST was published in 2000, many investigators, cooperative groups, industry and government authorities have adopted these criteria in the assessment.
  5. The revised RECIST guidelines (version 1.1) However, nodes that increase from for example 9mm to 11mm may not represent true disease progression, and we suggest that, providing that the change in the size of the node is the only evidence of progression,.
  6. e whether a tumor disappears, shrinks, stays the same or gets bigger. This is called complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD)

In contrast to RECIST 1.1, where new tumor lesions are considered qualitatively and directly denote 'progressive disease' and end of study, within iRECIST, they are differentiated into new measurable and non-measurable lesions RECIST 1.0: progressive disease -unequivocal progression of existing nontarget lesions. (Note: Although a clear progression of non-target lesions only is exceptional, in such circumstances, the opinion of the treating physician should prevail and the progression status should be confirmed later by the review panel [or study chair])

Disease progression is clarified in several aspects: in addition to the previ-ous definition of progression in target disease of 20% increase in sum, a 5 mm absolute RECIST guidelines includes updates that touch on all these points. EUROPEANJOURNALOFCANCER45 (2009). Response evaluation criteria in solid tumors or RECIST refers to a set of published rules used to assess tumor burden in order to provide an objective assessment of response to therapy. They were initially introduced in 2000 and have undergone subsequent revision in 2009 (RECIST 1.1) RECIST is an evolving standardized framework for evaluating changes in tumor size, that is used in clinical trials to define treatment responses and disease progression. 19 RECIST 1.1 and iRECIST are unsuitable for IT immunotherapy trials for several reasons 일부 환자의 경 우, RECIST 1.1과 같은 전통적인 반응 기준에 의하면 질병 진행 (disease progression) 기준에 부합한 영상소견이 보 인 후에 종양이 감소하는 지연성 반응이 나타났다 (10-12) Progression-free survival (PFS) as determined by the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) is the reference standard for assessing the therapeutic efficacy of many cancer treatments (2, 3), including for patients with clear cell renal cell carcinoma

Response Evaluation Criteria In Solid Tumors (RECIST), deutsch etwa Kriterien für die Bewertung des Ansprechens der Behandlung bei soliden Tumoren, ist eine Sammlung von veröffentlichten Regeln, die die Bewertung der Behandlungserfolge von Krebserkrankungen in medizinischen Forschungsstudien objektivieren sollen RECIST 1.1 Guidelines RECIST 1.1 Guidelines Measurable Tumor Burden A maximum of 10 target lesions in total (and u pt o5 er rgan) ca nbe i de tifie progression of non-target disease, the increase in overall tumor burden must be comparable to the increase require RECIST 1.0: No absolute increase in size required RECIST 1.1: Target Lesions: > 20% increase in the SLD taking as reference the smallest SLD recorded since the treatment started (nadir) and minimum 5 mm increase over the nadi This phenomenon may also occur in renal cell carcinoma: in a study of the tumor growth kinetics of patients receiving sunitinib for advanced disease (described further below) , the authors suggested that discontinuation of sunitinib in patients who exhibited indolent RECIST progression led to an acceleration of growth and a shorter survival than if sunitinib had been continued longer Median overall survival in patients with RECIST-defined progressive disease given anti-PD-1 antibody was longer in the treatment beyond progression cohort (24·4 months, 95% CI 21·2-26·3) than in the cohort of patients who did not receive treatment beyond progression (11·2 months, 10·1-12·9). 362 (54%) of 669 patients in the no treatment beyond progression cohort had a serious adverse.

PD Appearance of one or more new lesions and/or unequivocal progression of existing nontarget lesions Note—CR = complete response, PR = partial response, PD = progressive disease, SD = stable disease. A Fig. 4—Response assessment. A and B, Baseline CT scans of abdomen in 68-year-old man with colon cancer show two target lesions (arrow) in. Since then, disease progression needs to be confirmed in a second tumor assessment performed at least 4 weeks apart in clinically stable patients by means of new response criteria such as immune-related response criteria (irRC), immune-related RECIST (irRECIST), or immune RECIST (iRECIST; refs RECIST guideline (version 1.1)」を、当該雑誌の出版元であるエルゼビア社の許諾を正式に得て日本語に訳したものである。 翻訳作業は、厚 生労働省がん研究助成金計画研究20-15「画像によるがんの診断、治療法選択、治療効果判定に関する研究」班(主任研究者-渡辺裕一

iRECIST: guidelines for response criteria for use in

RECIST also adopted a different shrinkage threshold for definitions of tumour response and progression. For the WHO Criteria it had been >50% tumour shrinkage for a Partial Response and >25% tumour increase for Progressive Disease. For RECIST it was >30% shrinkage for a Partial Response and >20% increase for Progressive Disease RECISTとは、固形がんに対する治療が効いているか、効いていないかという判定に用いる評価基準です。Response Evaluation Criteria in Solid Tumorsの略であり、レシストといいます。 治療開始前に腫瘍の大きさをCTなどの画像診断で計測し、大きな腫瘍5つを選びそれを標的病変と呼び、それ以外の腫瘍を非.

RECIST disease assessment is effective for targeted

  1. Our analyses of progression-free survival (ie, iPFS per iRECIST and PFS per RECIST V.1.1) were calculated from the date of randomization to the date of disease progression by iRECIST/RECIST V.1.1 or death, whichever occurred earlier
  2. Amongst these are whether fewer than 10 lesions can be assessed without affecting the overall assigned response for patients (or the conclusion about activity in trials); how to apply RECIST in randomised phase III trials where progression, not response, is the primary endpoint particularly if not all patients have measurable disease; whether or how to utilise newer imaging technologies such.
  3. ation of tumor response and driven subsequent drug approval for years. 5 By RECIST criteria, a significant increase in the size of.
  4. RECIST defined tumor progression as a 20% increase in the longest diameter (which translates into ~73% increase in the tumor volume), as com- pared with the WHO cutoff of 25% increase in surface area (which translates into ~40% increase in volume).1
  5. For example, if a 7-cm tumor that had shrunk to 2cm grows to 3cm, RECIST progression has occurred even if no new lesions have appeared and the patient remains asymptomatic. Small changes in tumor measurement can be seen in the setting of measurement variability alone (35)

Progressive disease (PO) O Not evaluaöle #100 T,hjs js an optional field, available to clarity the response as assessed by the Investigator Please report the date of the first imaging that snowed progressive disease per RE-CIST O O O O O O Complete response OCR) Partial response (PR) Stable disease (iSD) Unconfirmed progression (iUPD In accordance with iRECIST, patients with stable disease (iSD) or better after an initial unconfirmed progression of disease (iUPD) were evaluated after iUPD for iCR/iPR/iSD in the determination of iBOR. Analyses of OS and PFS were conducted in the intent- to-treat (as randomized) population

RECIST criteria may show progression of tumor more slowly than WHO criteria. RECIST 1.1 criteria (assessing a maximum of 5 tumor foci, vs. 10 in RECIST) result in a higher complete response rate than the original RECIST criteria, at least in lymph nodes. Variability appears greater in assessing progression than in assessing response Coy et al found that, unlike the RECIST consortium assumes, progression due to non-target tumor growth only is not a rare exception but is instead observable in close to one-fifth (18.5%) of patients with progressive disease; another 26.6% of patients had progressive disease because they developed new lesions

New response evaluation criteria in solid tumours: revised

RECIST criteria are used to evaluate a patient's response to the therapy used to treat their disease. The content of this appendix has been modified to fit the needs of th Following progression by RECIST 1.1, the next imaging assessment to evaluate tumor burden status should not be longer than 8 weeks later unless evi- dence exist that pseudo-progression is a known occurrence. It is always the decision of the patient and treating physician to continue or discontinue therapy RECIST 1.1 also updated the definition of disease progression. In addition to the original definition of a 20% increase in sum of the target lesions, it now also required a 5 mm absolute increase in the sum of target lesions (to prevent overcalling progression) Treatment Beyond First RECIST‐Defined Progression. Per protocol, TBP was permitted at the discretion of investigators in consultation with the study monitors if a patient demonstrated clinical benefit without rapid disease progression, tolerated nivolumab, maintained a stable performance status, and provided informed consent

Recist 1.1 - Recist

  1. Patients with a global deterioration of health status requiring discontinuation of treatment without objective evidence of disease progression at that time should be classified as having symptomatic deterioration. Every effort should be made to document the objective progression even after discontinuation of treatment
  2. disease 1.Best response recorded in measurable disease from treatment start to disease progression or recurrence 2.NC in nonmeasurable lesions will reduce a CR in measurable lesions to an overall PR 2.Non-PD in nontarget lesions(s) will reduce a CR in target lesions(s) to an overall PR 3.NC in nonmeasurable lesions will no
  3. ation and defines progressive disease as at least a 20% increase in the sum of diameters of up to 5 target lesions (2 lesions/organ), taking as reference the smallest sum on study and an absolute lesion increase of at least 5 mm or the appearance of new lesions (5)
  4. ed at baseline)
  5. .. 33 Although progressive disease in irRECIST also requires reconfirmation after the first evaluation of progression, the definition of confirmed progressive disease largely differs among..

We defined progression‐free survival 1 (PFS1) as the time from initial immunotherapy to RECIST 1.1‐defined first progressive disease or death, progression‐free survival 2 (PFS2) as the time from RECIST 1.1‐defined first progressive disease to iRECIST‐defined first progressive disease or death, and immune‐related progression‐free survival (iPFS) as the first date at which. RECIST Terminology To understand RECIST rules, you need to understand the following terms: • Measurable diseaseMeasurable disease • Nonmeasurable disease • Target lesion • Non-target lesion The next several slides will provide definitions. Measurable Disease • Disease which has at least 1 lesion that can be accurately measured in at leas RECIST updated, latest version - RECIST 1.1, was published tumor size signifies progressive disease o - Once progression is detected, drug cessation is recommended o Response after initial treatment of a cytotoxic agent can often predict remission and survival

Comparison of RECIST version 1

(RECIST ガイドライン) ―日本語訳JCOG版― SPECIAL ARTICLE New Guidelines to Evaluate the Response to Treatment in Solid Tumors Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer, Jantien Wanders, Richard S. Kaplan, Larry Rubinstein, Jaap Verweij, Martine Van Glabbeke, Allan T. van Oosterom, Michaele C. Christian, Steve G. Progression-free survival (PFS) and overall survival (OS) were compared between RECIST and the NPI.Results: ROC curve analysis identified two cutoff values based on the NPI (≤ −49.3% and ≥43.4%) to discriminate partial remission (NPR), stable disease (NSD) and progressive disease (NPD). Based on RECIST, survival analysis did not. investigate the time to event outcome of progression-free sur-vival with RECIST version 1.0 compared with the proposed re-vised criteria. Progression-free survival was analysed considering events which are either progression of disease (on the basis of the program for RECIST(n)), or death within 60 days of the last obtained measurements

We aimed to investigate the such prognostic impact of progression type by RECIST in pancreatic cancer. Methods We reviewed a retrospective data of total 228 histologically confirmed metastatic pancreatic adenocarcinoma patients treated with 1st line systemic chemotherapy and who showed progressive disease in response evaluation anytime during 1st line gemcitabine based chemotherapy from 2011. Disease progression is clarified in several aspects: in addition to the previous definition of progression in target disease of 20% increase in sum, a 5 mm absolute increase is now required as well to guard against over calling PD when the total sum is very small disease, and progressive disease are defined as in the WHO and RECIST criteria (Tables 1-3) (8). This type of clas-sification divides intrinsically continuous data (tumor size) into 4 bins, losing statistical power for ease of nomencla-ture and convenience (9). The time to tumor progression and progression-fre

The Radiology Assistant : RECIST 1

PPT - Assessing Response and Progression in Ovarian Cancer

The novelty of irRC is that it considered the patient's 'total tumor burden' and required confirmation of suspected disease progression with subsequent imaging, approximately four weeks later. irRC has been used in tandem with conventional response criteria such as RECIST and in current clinical protocols for prospective validation of immunotherapeutic agents such as ipilimumab In fact, only 54.4% of patients could continue erlotinib on RECIST disease progression in a single-arm, phase II study that prospectively evaluated the efficacy of continuing erlotinib.21 In our study, 37% of patients (group A) were clinically unstable due to disease progression, and the vast majority of them could not continue EGFR-TKI therapy at the time of first RECIST PD RECIST 1.1 Guidelines RECIST 1.1 Guidelines Measurable Tumor Burden A maximum of 10 target lesions in total (and up to 5 per organ) can be identified progression of non-target disease, the increase in overall tumor burden must be comparable to the increase require Automated RECIST measurement with Deep Learning, as performed by RSIP Vision and other researchers, is confirmed to produce scores annotations with less variability with shorter use of expert time. This fully automated procedure proves to be very precious along clinical trials aimed at verifying whether a new drug leads to complete response, partial response, stable disease or progressive disease

progression-free survival (PFS) without a ecting RECIST response rates [11]. Others have reported morphological changes independent of reductions in tumor size but correlating with pathological responses following treatment with bevacizumab in patients with CRC liver metastases [9] Both clinical objective response and time to development of disease progression (progression-free survival) are important endpoint in phase II clinical trials in advanced breast cancer. However, many clinical trials ( 4-9 ) established that pathologic complete response (pCR) is of greater importance for patient outcome than clinical response Have progression of unresectable LA/M breast cancer after last systemic therapy (as confirmed by investigator), or be intolerant of last systemic therapy; Have measurable disease assessable by RECIST v1.1; Have Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0 or radiographic progression based on RECIST 1.1, the investigator makes a decision. If the subject is clinically stable-and that means stable performance status, no worsening signs or symptoms of disease (which can include laboratory abnormalities), and no progression that requires urgent intervention or change i Represent progression regardless of measurability ! Should be unequivocal ! New bone lesions may represent healing or a flare ! Equivocal lesions should be confirmed ! If subsequently shown to represent new disease, the date of progression should be the date of the initial scan ! When a lesion is seen in an anatomic area no

iRECIST: how to do it Cancer Imaging Full Tex

The primary endpoint is progression-free survival (PFS) as determined by blinded independent central review using RECIST v1.1. Key secondary endpoint is overall survival (OS) Among the 78 patients who continued therapy and imaging post-progression, RECIST 1.1 and iRECIST were discordant in 10 patients (12.8%) and pseudoprogression was encountered in 14 patients (17.9%). OS of patients with pseudoprogression was longer than that of patients with uncontrolled disease/true progression (29.9 months versus 8.0 months, p value < 0.001) In CheckMate 141, patients METHODS: with RECIST-defined progression who had a stable performance status and demonstrated clinical benefit without rapid disease progression were permitted to receive TBP with nivolumab at 3 mg/kg every 2 weeks until further progression, which was defined as an additional 10% increase in tumor volume

Defined as progression despite androgen depletion therapy levels, the progression of pre-existing disease, and/or the appearance of new metastases. PCWG provides a guideline for clinical trial for pts with CRPC Started in 2008 when taxels only Rx available; emerging drugs PCWG3 adopts RECIST 1.1 guidelines Measurement of disease progression using the RECIST 1.1 criteria. (a) Axial CT of the pelvis and abdomen of a patient with renal cell carcinoma demonstrates a

Comparison of RECIST 1

Change 12: Definition of Unequivocal Progression - RECIST 1

Progression exceptions and notes PD in Effusion/Ascites Positive cytology must be obtained PD in Non-targets only Must document that the progression represents the patients overall disease status change PD in new Lymph Node lesions Subclinical LNs present at baseline must increase to > 15mm or have pathological confirmation o Progression is defined according to RECIST but can also be based upon serum CA 125 (defined below) but tumour measurements should take precedence over CA 125. If measurable disease is shrinking during treatment, but the CA 125 indicates progression (as defined below) the patient should continue to receive protocol treatment RECIST criteria, which defines when cancer patients improve (respond), stay the same (stable), or get worsen (progression) during antitumor treatments, was first published in February 2000 by an international collaboration group including the European Organization for Research and Treatment of Cancer (EORTC), National Cancer Institute (NCI) of the United States, and the National Cancer Institute of Canada Clinical Trials Group iUPD is defined by RECIST 1.1 target lesion progression disease, and iCR, iPR and iSD can all be assigned after iUPD been recorded, as long as not confirmed. The confirmation of iUPD (in target lesion category), is done by a further increase in sum of diameter of the target lesion greater than 5 mm in the next assessment within 4 to 8 weeks RECIST 1.0 RECIST 1.1 RECIST 1.0 RECIST 1.1 Measuring tumor burden 10 targets 5 per organ 5 targets (2 per organ, ≥10 mm) Lymph node Measure long axis as for other lesion. Silent on normal size Measure short axis Define normal size (10 mm) Progression Definition 20% increase in sum 20% increase and at least 5 mm absolute increase Non.

progression identified. Persistent or increase in number of lesions on bone scan compared to prior scan. Disease progression on bone scan under PCWG2 is defined as: Note: 2 or more lesions that have fused (become 1) since prior assessment should continue to be counted as original number. A single lesion that has split (divided (PFS4), both by the RECIST and the Rustin criteria, were considered as an indicator of the ultimate treatment success. The variable platinum free interval (PFI) was defined as the time period from the end of initial platinum therapy to disease progression before the start of protocol therapy (either PLD or trabectedin plus PLD). Result The criteria for defining progression are now acceptable in clinical trials of recurrent disease as they have since been validated (Pujade-Lauraine, personal communication, 2010). The GCIG requests that data from all clinical trials using these definitions are made available to GCIG trial centers so that continual validation and improvement can be accomplished The primary endpoint of the study was evidence of radiographic progression as determined by RECIST version 1.1 (1) or clinical response evaluation. Measurable disease changes by imaging were interpreted by an independent radiologist, who was blinded to the assessment of molecular response

Response evaluation criteria in solid tumors Radiology

Please see further explanations for assessment of progression of non-target disease in section 4.3.3 and 4.4.4 of the RECIST guideline (see reference section). We will not provide programming examples in this paper. AN EXAMPLE TO DERIVE TARGET LESION RESPONSE TR (Tumor Results) Domai Poor concordance between CA-125 and RECIST at the time of disease progression in patients with platinum-resistant ovarian cancer: analysis of the AURELIA trial. Annals of Oncology, Jul 2016 K. Lindemann, G. Kristensen, M. R. Mirza.

Response Criteria for Intratumoral Immunotherapy in Solid

Patients who discontinued nivolumab were not eligible for nivolumab treatment beyond progression, but a temporary hold to manage a toxicity before first progression was allowed. First progression (RECIST) was defined as ≥20% increase in the sum of target lesions or appearance of ≥1 new lesion [ 1 Overall Survival, Best Overall Response as per RECIST criteria, Progression Free Survival (PFS), Time to Progression (TTP), Best Overall Response Rate are some of the key efficacy indicators that will be discussed. INTRODUCTION Initially tumor response rate was sufficient for FDA approval of oncologic drugs Nevertheless, until data from prospective studies are available whenever CA-125-defined progression of malignant disease is found, confirmation per the RECIST is advisable. Early CA-125 response was a helpful, but not optimal, predictor of ultimate best radiological response NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine

Categorization of Overall Disease Response with RECIST

Components of Radiologic Progressive Disease Defined by

RECIST(v1.1)— 实体瘤 Chest X-ray: Chest CT is preferred over chest X-ray, particularly when progression is an important endpoint, since CT is they must normalise for a patient to be considered in complete response. Because tumour markers are disease specific, instructions for their measurement should be incorporated. Median progression free survival was 28 months. If the RECIST 1.1. was applied, the best effect was OR in 13 (17%), SD in 54 (68%) and progressive disease (PD) in 12 (15%) patients. Based on the RECIST 1.1., the median progression free survival, was 33 months However, RECIST rules carry some subjectivity that represents a potential factor for inter-reader variability. Poor guidance in reporting new lesions, in reporting progression of non-target lesions or in the optimal use of window level to visualize lesions, are factors that may lead to subjective assessments

Response Evaluation Criteria in Solid Tumors - Wikipedi

Progressive disease is a term that describes a disease that is progressing or worsening. With cancer, progressive disease is defined as at least a 20 percent growth in the size of the tumor or spread of the tumor since the beginning of treatment Progression of local prostate disease: Use RECIST v1.1 for progression criteria above applied to local disease Progression of nodes (short axis) <1.0 cm nodes have to have grown by at least 5mm in from baseline or treatment nadir and be ≥1 cm to be considered to have progresse New criteria, known as RECIST (Response Evaluation Criteria in Solid Tumours), were pub- lished in 2000 • Clinicians with expertise in early drug development from academic research organisations, government and industry, together with imag- ing specialists and statisticians • Because the fundamental approach to assessment remains grounded in the anatomical, rather than functional. *Nontarget lesions include ascites and peritoneal thickening, which are not measurable according to RECIST. †Unequivocal progression in nontarget lesions may be accepted as disease progression. CR, Complete response; PD, progressive disease; PR, partial response; SD, stable disease. TABLE 3 Ascites 2 4.3 - - Gastrointestinal ulcer 3b 6.4 2c 4.3 a The Child -Turcott Pugh class increased from A to B in 6 patients (12.8%) and reduced from B to A in 1 patient (2.1%). bGastroduodenal ulcer or colonic ulcer cGastric ulcer perforatio

RECIST 1.1 - Parexel Informatic

Disease progression by RECIST with a 2-fold increase in tumor growth rate (TGR) upon treatment (experimental period) vs before treatment (reference period) •Time to treatment failure less than 2 months •Rate of hyperprogression: reported about 4% to 29 RECIST criteria were applied to determine the tumor response; however, only 2 of these 9 trials (ANBL0322 and ANBL0421) met the objective response rate bar for success as prospectively defined per protocol. 6, 7 This highlights the need for additional agents to be tested in the phase 2 setting, and suggests that the assessment of progression‐free survival (PFS), time to disease progression. RECIST criteria (Response Evaluation Criteria in solid Tumors) are guidelines to evaluate the tumor progression or response to therapy. In most oncology studies the tumor burden is evaluated using the RECIST criteria. The guidelines are easy to understand but implementing them is not. Tumors might split or merge, disappear and reappear 安定(stable disease; SD) 進行(progressive disease; PD) の4つのカテゴリーは踏襲 (2) 新旧の規準間にPRの意味や概念上の大きな相違が 生じないよう配慮 (3) 判定方法の標準化と単純化 (4) 判定におけるアルファエラーを小さくする RECIST はじめに(4) 臨床第II 試

When Progressive Disease Does Not Mean Treatment Failure

Edits to Protocol Section 10: Lymph Nodes and Progression Refresher on how RECIST 1.1 deals with lymph nodes At baseline: LNs <1.0 cm in short axis = non-pathological, should not be recorded or followed LNs ≥ 1.0 cm and < 1.5 cm in short axis: abnorma Radiographic progression was defined as either Response Evaluation Criteria In Solid Tumors (RECIST) or bone scan progression defined as two or more new lesions at the initial after treatment assessment confirmed by additional lesions ≥6 weeks later, or two or more new lesions at any time beyond the initial post‐treatment assessment, which accounts for the potential misclassification of. T1 - Modified recist (mRECIST) assessment for hepatocellular carcinoma. AU - Lencioni, Riccardo. AU - Llovet, Josep M. PY - 2010/3/3. Y1 - 2010/3/3. N2 - The endpoint in cancer research is overall survival. Nonetheless, other potential surrogate endpoints, such as response rate and time to progression, are currently used In 2009, major revisions were made (resulting in RECIST 1.1), including a reduction in the number of assessed lesions, a new method to classify lymph nodes, clarifications related to a complete response (CR) or partial response (PR) and new methods for measuring disease progression. Of note, RECIST 1.1 states that the finding of a new lesion. The primary end point was investigator-assessed progression-free survival, which was defined as the time from randomization to radiologically confirmed disease progression, according to RECIST.

progression or death from any cause) was also assessed based on RECIST 1.1 and iRECIST in order to calculate progression- free survival (PFS) according to each tumor response assess-ment criteria. Pseudoprogression Cases of PsP are those that were defined as PD on RECIST 1. Poor concordance between CA-125 and RECIST at the time of disease progression in patients with platinum-resistant ovarian cancer: analysis of the AURELIA trial. Annals of Oncology, Aug 2016 Lindemann, K., Kristensen, G., Mirza. We considered the duration between treatment initiation to the time of progression or the last follow-up visit for patients who had not progressed - the sequence was defined as RECIST criteria version 1.1. Disease-free survival was considered as the duration while the person experienced complete remission

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